Immunohistochemical detection of epidermal growth factor receptors on human colonic carcinomas
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چکیده
منابع مشابه
Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.
We describe the properties of two monoclonal antibodies produced to a synthetic peptide consisting of residues 985 to 996 from the cytoplasmic domain of the epidermal growth factor (EGF) receptor. We have examined a group of ten human tumors including cervical, ovarian, and vulval carcinomas for expression of EGF receptors by immunohistological staining using one of these antibodies and another...
متن کاملGastric and Colonic Carcinomas Expression of Epidermal Growth Factor Receptor in Human
The expression of epidermal growth factor (EGF) receptor was ex amined immunohistochemically in a total of 122 gastric and 61 colonie carcinomas, out of which 16 gastric and 8 colonie carcinomas were also examined by I2sl-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 ±1.98 (SE; n = 16) fmol/mg protein in gastric carcinomas and 5.72 ±2.15 (n = 8) fmol/...
متن کاملExpression of epidermal growth factor receptor in human gastric and colonic carcinomas.
The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (SE; n = 16) fmol/mg protein in gastric carcinomas and 5.72 +/- 2.15 (n = 8) fm...
متن کاملImmunohistochemical Expression of Epidermal Growth Factor Receptor in Different Grades of Oral Squamous Cell Carcinomas
head and neck carcinomas. Of all the cancers worldwide, its prevalence rate is 5%.1 Globally, about two-thirds of oral cancers occur in developing countries, and it is a major health hazard. The highest prevalence of oral cancer has been observed in the Indian subcontinent,2 where huge populations are open to the elements, exterior irritants, and carcinogens, such as smoke, tobacco, and betel n...
متن کاملModulation of epidermal growth factor receptors by human alpha interferon.
Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding of 125I-labeled epidermal growth factor (EGF) at 4 degrees C. Human IFN-beta and -gamma, which exhibit little antiviral and antiproliferative activities on MDBK cells, have little effect on cell gr...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1990
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1990.63